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List of nanopore research groups

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Academic laboratories that work on nanopores
For the atlas of 2,112 research groups and companies, see The Hole World.

This is a list of nanopore research groups: university laboratories that make, study or use nanopores and have published on them in recent years. It is short by design. The Hole World, an atlas published by Molecular Reality Corporation, holds 1,596 academic groups, and it rates 1,261 of its 2,112 entries as low certainty and badges them "unverified".[1] Each row below rests on a paper from the group, and a search of Europe PMC in October 2026 found papers mentioning nanopores, dated 2023 to 2026, for every group listed.[2]

Groups are named for their principal investigators, as laboratories usually are, and the name follows the person from one institution to another. The table gives the lab name, the institution and the work the cited paper reports. It does not describe the people.

Groups

Academic nanopore groups with a recent publication record
Group Institution City, country Work shown by the cited paper
Bayley group University of Oxford Oxford, United Kingdom Engineered protein pores that detect single molecules by stochastic sensing, the research behind Oxford Nanopore Technologies[3]
Keyser group University of Cambridge Cambridge, United Kingdom DNA nanostructures used as carriers and labels for protein sensing;[4] glass nanocapillaries, a form of glass nanopipette[5]
Howorka group University College London London, United Kingdom DNA-based pores that span lipid membranes[6]
Loose lab University of Nottingham Nottingham, United Kingdom "Read Until", the selection of molecules for sequencing while they are in the pore[7]
Ying group Nottingham Trent University Nottingham, United Kingdom Tracking the assembly and disassembly of single ferritin molecules with polymer-coated nanopores[8]
Dekker lab Delft University of Technology Delft, Netherlands Solid-state nanopores of single-nanometer size, shrunk with an electron beam;[9] rereading single proteins with nanopores[10]
Maglia group University of Groningen Groningen, Netherlands An engineered protein pore that passes full-length proteins[11]
Radenovic lab École Polytechnique Fédérale de Lausanne Lausanne, Switzerland Pores in molybdenum disulfide, a two-dimensional material[12]
Mayer group University of Fribourg Fribourg, Switzerland Trapping single proteins in nanopores with reversible covalent bonds[13]
Oukhaled group CY Cergy Paris Université Cergy, France Electrical recognition of the twenty proteinogenic amino acids with an aerolysin pore[14]
Simmel group Technical University of Munich Munich, Germany Membrane channels formed by designed DNA nanostructures[15]
Meller group Technion Haifa, Israel Classification of full-length proteins by cysteine fingerprinting in solid-state pores[16]
Gundlach group University of Washington Seattle, United States Reading DNA with a mutant MspA pore and a polymerase[17]
Gu group University of Missouri Columbia, United States A nanopore used as a sensor of nucleic acid conformation, to detect interactions between aptamers and small molecules in real time[18]
Akeson lab University of California, Santa Cruz Santa Cruz, United States Forward and reverse ratcheting of DNA through a nanopore at 5-ångström precision[19]
Drndic lab University of Pennsylvania Philadelphia, United States DNA translocation through graphene nanopores[20]
Wanunu lab Northeastern University Boston, United States Osmium tags that improve base discrimination in nanopore sequencing[21]
White lab University of Utah Salt Lake City, United States A multipass Coulter counter that measures a particle many times[22]
Siwy lab University of California, Irvine Irvine, United States Synthetic pores that act as ion pumps;[23] pores whose opening diameter changes in time[24]
Dwyer lab University of Rhode Island Kingston, United States Making a pore with a handheld arc lighter, described in Tesla coil lighter pore fabrication[25]
Aksimentiev group University of Illinois Urbana-Champaign Urbana, United States All-atom simulation of nanopore blockade currents[26]
Timp lab Johns Hopkins University Baltimore, United States Detecting DNA methylation in nanopore sequencing data[27]
Tabard-Cossa lab University of Ottawa Ottawa, Canada Making pores by controlled dielectric breakdown[28]
Reisner lab McGill University Montreal, Canada DNA nanostructures characterized by resensing in a pair of nanopores[29]
Taniguchi lab Osaka University Osaka, Japan Identifying viruses from nanopore current with machine learning, as in Aipore[30]
Uemura lab University of Tokyo Tokyo, Japan Profiling a nanopore's response across voltages to tell protein mixtures apart[31]
Kawano lab Tokyo University of Agriculture and Technology Tokyo, Japan A peptide, made in a cell-free system, that forms β-barrel nanopores[32]
Huang group Nanjing University Nanjing, China Discriminating all 20 proteinogenic amino acids and their modifications with a nanopore[33]

Earlier groups

The experiment that opened nanopore sequencing, in 1996, passed single strands of DNA through a protein channel in work from the National Institute of Standards and Technology, Harvard and the University of California, Santa Cruz.[34] In 2001 a group at Harvard sculpted a pore in silicon nitride with a low-energy ion beam.[35]

Groups not listed

Flagship entries in the atlas include groups in Amherst, Tempe, New Haven and Notre Dame, and in Cambridge, Massachusetts, which this list does not cover.[1]

See also

References

  1. ^ a b "The Hole World: build metadata". Molecular Reality Corporation. September 26, 2026.
  2. ^ "Europe PMC". EMBL-EBI. Retrieved October 25, 2026.
  3. ^ Gu et al. (1999). "Stochastic sensing of organic analytes by a pore-forming protein containing a molecular adapter". Nature 398: 686-690. doi:10.1038/19491.
  4. ^ Bell; Keyser (2016). "Digitally encoded DNA nanostructures for multiplexed, single-molecule protein sensing with nanopores". Nature Nanotechnology 11: 645-651. doi:10.1038/nnano.2016.50.
  5. ^ Steinbock et al. (2010). "Detecting DNA folding with nanocapillaries". Nano Letters 10: 2493-2497. doi:10.1021/nl100997s.
  6. ^ Burns et al. (2013). "Lipid-bilayer-spanning DNA nanopores with a bifunctional porphyrin anchor". Angewandte Chemie International Edition 52: 12069-12072. doi:10.1002/anie.201305765.
  7. ^ Loose; Malla; Stout (2016). "Real-time selective sequencing using nanopore technology". Nature Methods 13: 751-754. doi:10.1038/nmeth.3930.
  8. ^ Assadipapari et al. (2026). "Tracking single-molecule ferritin reassembly and disassembly using polymer-coated nanopores". Nanoscale 18: 1045-1054. doi:10.1039/d5nr02885j.
  9. ^ Storm et al. (2003). "Fabrication of solid-state nanopores with single-nanometre precision". Nature Materials 2: 537-540. doi:10.1038/nmat941.
  10. ^ Brinkerhoff et al. (2021). "Multiple rereads of single proteins at single-amino acid resolution using nanopores". Science 374: 1509-1513. doi:10.1126/science.abl4381.
  11. ^ Sauciuc et al. (2024). "Translocation of linearized full-length proteins through an engineered nanopore under opposing electrophoretic force". Nature Biotechnology 42: 1275-1281. doi:10.1038/s41587-023-01954-x.
  12. ^ Feng et al. (2015). "Identification of single nucleotides in MoS2 nanopores". Nature Nanotechnology 10: 1070-1076. doi:10.1038/nnano.2015.219.
  13. ^ Li et al. (2026). "Selective and controllable trapping of single proteins in nanopores using reversible covalent bonds". ACS Nano 20: 879-891. doi:10.1021/acsnano.5c16000.
  14. ^ Ouldali et al. (2020). "Electrical recognition of the twenty proteinogenic amino acids using an aerolysin nanopore". Nature Biotechnology 38: 176-181. doi:10.1038/s41587-019-0345-2.
  15. ^ Langecker et al. (2012). "Synthetic lipid membrane channels formed by designed DNA nanostructures". Science 338: 932-936. doi:10.1126/science.1225624.
  16. ^ Soni et al. (2025). "Full-length protein classification via cysteine fingerprinting in solid-state nanopores". Nature Nanotechnology 20: 1482-1490. doi:10.1038/s41565-025-02016-w.
  17. ^ Manrao et al. (2012). "Reading DNA at single-nucleotide resolution with a mutant MspA nanopore and phi29 DNA polymerase". Nature Biotechnology 30: 349-353. doi:10.1038/nbt.2171.
  18. ^ Chingarande et al. (2023). "Real-time label-free detection of dynamic aptamer-small molecule interactions using a nanopore nucleic acid conformational sensor". Proceedings of the National Academy of Sciences 120: e2108118120. doi:10.1073/pnas.2108118120.
  19. ^ Cherf et al. (2012). "Automated forward and reverse ratcheting of DNA in a nanopore at 5-Å precision". Nature Biotechnology 30: 344-348. doi:10.1038/nbt.2147.
  20. ^ Merchant et al. (2010). "DNA translocation through graphene nanopores". Nano Letters 10: 2915-2921. doi:10.1021/nl101046t.
  21. ^ Henley et al. (2015). "Osmium-based pyrimidine contrast tags for enhanced nanopore-based DNA base discrimination". PLOS ONE 10: e0142155. doi:10.1371/journal.pone.0142155.
  22. ^ Edwards; White (2015). "High-speed multipass Coulter counter with ultrahigh resolution". ACS Nano 9: 12274-12282. doi:10.1021/acsnano.5b05554.
  23. ^ Siwy et al. (2002). "Fabrication of a synthetic nanopore ion pump". Physical Review Letters 89: 198103. doi:10.1103/PhysRevLett.89.198103.
  24. ^ Silva et al. (2026). "Nanopores with dynamic pore opening diameter". Faraday Discussions 266: 377-398. doi:10.1039/d6fd00004e.
  25. ^ Bandara; Karawdeniya; Dwyer (2019). "Push-button method to create nanopores using a Tesla-coil lighter". ACS Omega 4: 226-230. doi:10.1021/acsomega.8b02660.
  26. ^ Liu et al. (2026). "Improving all-atom molecular dynamics models for quantitative prediction of nanopore blockade current". Journal of Chemical Theory and Computation 22: 10445-10464. doi:10.1021/acs.jctc.6c01180.
  27. ^ Simpson et al. (2017). "Detecting DNA cytosine methylation using nanopore sequencing". Nature Methods 14: 407-410. doi:10.1038/nmeth.4184.
  28. ^ Kwok; Briggs; Tabard-Cossa (2014). "Nanopore fabrication by controlled dielectric breakdown". PLoS ONE 9: e92880. doi:10.1371/journal.pone.0092880.
  29. ^ Dong et al. (2025). "DNA nanostructures characterized via dual nanopore resensing". ACS Nano 19: 35539-35550. doi:10.1021/acsnano.5c09529.
  30. ^ Taniguchi et al. (2021). "Combining machine learning and nanopore construction creates an artificial intelligence nanopore for coronavirus detection". Nature Communications 12: 3726. doi:10.1038/s41467-021-24001-2.
  31. ^ Akita et al. (2025). "Voltage-matrix nanopore profiling for the discrimination of protein mixtures". Chemical Science 16: 18607-18615. doi:10.1039/d5sc05182g.
  32. ^ Fujita; Sato; Kawano (2026). "Liposome-supplemented cell-free synthesis of a peptide that forms β-barrel nanopores". ACS Nano 20: 25993-26005. doi:10.1021/acsnano.5c15163.
  33. ^ Wang et al. (2024). "Unambiguous discrimination of all 20 proteinogenic amino acids and their modifications by nanopore". Nature Methods 21: 92-101. doi:10.1038/s41592-023-02021-8.
  34. ^ Kasianowicz et al. (1996). "Characterization of individual polynucleotide molecules using a membrane channel". Proceedings of the National Academy of Sciences 93: 13770-13773. doi:10.1073/pnas.93.24.13770.
  35. ^ Li et al. (2001). "Ion-beam sculpting at nanometre length scales". Nature 412: 166-169. doi:10.1038/35084037.
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